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讲述4个宅男科学家的情景喜剧。为人老实略显呆板的莱纳德与美女女友佩妮的恋情平稳发展，然而他俩始终不触及婚姻这个大问题。“谢耳朵”谢尔顿是个大奇葩，人人都爱他，当然最爱他的，要数他的生物学家女友艾米。霍华德与老婆伯纳黛特过着幸福小日子，而拉杰什终于做到不靠酒精就可以和女性说话了，可他还是光棍一条，属于他的春天何时到来？。Margot and David come from different worlds. She is heiress to a hotel empire. He has to work three jobs to make ends meet. But when their paths come together, they realise that only they can help each other win back the love of their lives.。